PHYSICOCHEMICAL STUDIES OF THE REACTION OF 99mTc WITH 2- THIOURACIL AND 5-NITROBARBITURIC ACID UNDER DIFFERENT CONDITIONS

Document Type : Original Article

Authors

1 Faculty of Science, Alexandria University.

2 International Medical Center.

Abstract

ABSTRACT
The reaction of 99mTc of different oxidation states (+7, +4) with 2-thiouracil and 5-
nitrobarbituric acid have been studied at different temperatures, pH and concentrations.
The reaction mixtures have been analyzed at different times using TLC and a
radiodetctor to show the peaks at the plates.99mTc is obtained from the Mo generators
with oxidation state (+7). The use of SnCl2 as a reducing agent gave 99mTc with
oxidation state (+4). It is very difficult to separate the complexes formed from the
reactions in very small concentration. The percentage of 99mTc and its oxidation state
involved the complexes can be determined.

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